Argentine striker Aguero netted all his goals in a devastating second-half showing - twice finishing from Kevin de Bruyne's ideal passes, punishing a Kasper Schmeichel error by chipping into the net and curling in a sublime fourth. "Now it's important to move on together and prepare for the next game".
After a sluggish first half in the early kickoff at Wembley, Kane jumped highest to head home his seventh derby goal in seven games and 23rd in the league this season.
Leicester named City target Riyad Mahrez among the substitutes after he ended a self-imposed exile which saw him miss their last two matches.
But it didn't take long for the home side to show the abundance of talent they have going forward despite missing out on Mahrez and coping with a series of injuries to the likes of Leroy Sane and Gabriel Jesus.
Aguero again was the beneficiary of Kevin De Bruyne's mastery, this time finding the striker with a neat through ball, before Aguero cannoned his shot past Schmeichel and into the net.
Rory McIlroy responds to Jason Day's desire comment McIlroy was four-under through 15 holes before suffering a bogey on the 16th, when his wayward drive finished in a waste area. Americans dominate the leaderboard with Kevin Streelman and Beau Hossler leading the way after round 1 on seven under par.
"With that spirit and with a lot of problems - today we had three guys from the second team on the bench because we have a lot of problems".
With the pair ably backed by a sensational supporting cast, including Leroy Sane, David Silva, Raheem Sterling and Gabriel Jesus, City have scored 20 more goals than the next-best attacking side, Liverpool, and amassed 16 points more than city rivals United, in second place.
Then, at the death, Aguero got his fourth and City's fifth of the game, via an outstanding strike from outside the box.
After 25 minutes of patience and control, Aguero finally managed to bag his hat-trick, thanks mostly to a shocking piece of play by KasperSchmeichel.
Shortly after De Bruyne produced another masterclass in the centre, teammate Benjamin Mendy reacted with an epic post on Twitter.
However, Sterling's England team-mate Jamie Vardy leveled the scores before the half-hour mark after a fine run.
High school graduation rate edges past 80 percent
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Black Panther director wanted to include Kraven the Hunter
Best-known as a Spider-Man villain, Kraven's MO is to go after superheroes with animal names and mount their heads on his wall. In July 2017 it was reported that Sony, who control the Spider-Man film rights, were developing a film featuring Kraven.
Germany: Schulz gives up Foreign Ministry portfolio
He is not the only one feeling let down by the results of party leaders' days-long negotiating marathon earlier this week. Merkel faced an uphill struggle to maintain power for another four years following a disastrous election campaign.
Trump's stunner! Beats Obama in approval
Voters contend Trump is doing more to divide the country than to unite it by 60 percent to 35 percent. More than half of respondents - 51 percent - approved of Trump's handling of the economy.
Joaquin Phoenix in Talks to Star in The Joker Standalone Film
Todd Phillips ( The Hangover , War Dogs ) is directing and co-writing the script with Scott Silver ( 8 Mile , The Fighter ). The source also reports that the potential film will take place in the '80s and will have grittier look at crime in Gotham.
Bollywood mourns death of Pakistani activist Asma Jahangir
In 2007, she was placed under house arrest for participating in a movement to restore judges removed by then military ruler Gen. She was attacked for advocating peace with India, and was often accused of being an Indian agent or a traitor.